CELL BIOLOGY POLLARD AND EARNSHAW PDF

This critically acclaimed textbook offers you a modern and unique approach to the study of cell biology. It emphasizes that cellular structure, function, and dysfunction ultimately result from specific macromolecular interactions. The exquisite art program helps you to better visualize molecular structures. Covers essential concepts in a more efficient, reader-friendly manner than most other texts on this subject. Progresses logically from an explanation of the "hardware" of molecules and cells to an understanding of how these structures function in the organism in both healthy and diseased states. Helps you to visualize molecular structures and functions with over remarkable full-color illustrations that present physical structures to scale.

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The third edition has over new and revised figures. The thoroughly revised text includes the latest concepts and information on every aspect of cell biology, super-resolution microscopy, high throughput genomics and other cutting-edge methods.

Cell Biology e3 covers more material and in fewer pages than the previous edition. Twenty-four chapters by leading researchers cover every aspect of the cytoskeleton and cellular motility. Research Overview Our laboratory uses a combination of biochemistry, biophysics, microscopy and fission yeast genetics to investigate the molecular basis of cellular motility and cytokinesis.

Actin-based cellular movements are essential for shaping organs during embryonic development, defense against microorganisms and wiring the nervous system. Movement of cells out of primary tumors is the chief cause of mortality in cancer.

Cytokinesis is essential for the replication of all cells and is still one of the least understood aspects of cell division. We have also pioneered the analysis of myosin-II function in fission yeast cytokinesis. Actin-based movements We study how cells control the assembly and disassembly of actin filaments during cellular movements. We have also helped to establish the molecular pathway of cytokinesis in fission yeast.

Ribbon diagram of the 2. Science Molecular mechanism of cytokinesis Over the past decade our lab adopted fission yeast as our model system for studying cytokinesis. We used quantitative fluorescence microscopy of fluorescent fusion proteins to establish the temporal and spatial pathway of contractile ring assembly and constriction and to measure the global and local concentrations of 30 proteins that participate in the process.

We characterized the biochemical properties of several of the cytokinesis proteins, including myosin-II, formins, profilin, capping protein and cofilin. We combined this information in mathematical models that allow us to test our hypotheses about the cytokinesis pathway and to suggest fruitful opportunities for new research.

Ref: Lee, W. Cell Biol. Thomas D. Pollard, M.

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Cell Biology

The third edition has over new and revised figures. The thoroughly revised text includes the latest concepts and information on every aspect of cell biology, super-resolution microscopy, high throughput genomics and other cutting-edge methods. Cell Biology e3 covers more material and in fewer pages than the previous edition. Twenty-four chapters by leading researchers cover every aspect of the cytoskeleton and cellular motility. Research Overview Our laboratory uses a combination of biochemistry, biophysics, microscopy and fission yeast genetics to investigate the molecular basis of cellular motility and cytokinesis. Actin-based cellular movements are essential for shaping organs during embryonic development, defense against microorganisms and wiring the nervous system. Movement of cells out of primary tumors is the chief cause of mortality in cancer.

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Life in the atomic age

About the Author Thomas Pollard Thomas Dean Pollard is a prominent educator, cell biologist and biophysicist whose research focuses on understanding cell motility through the study of actin filaments and myosin motors. Earnshaw is an elected Fellow of the Royal Society since for his studies of mitotic chromosome structure and segregation. Her lab uses live cell imaging approaches to analyze the spatio-temporal behaviour and dynamic interactions of molecules in cells with a special focus on neurobiology. Her work there included a collaboration with physicists Eric Betzig and Harald Hess now group leaders at Janelia , who proposed a new function for the photoactivatable protein. The scientists used the protein to generate photoactivatable fluorophores, or dyes, which enabled them to illuminate different sets of molecules sequentially, creating a microscope image far more detailed than previously possible. The method, called super-resolution microscopy, garnered Betzig the Nobel Prize in Chemistry.

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